Cationic Surfactants as Disinfectants against SARS-CoV-2 |
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| Authors: | Eduard V Karamov Viktor F Larichev Galina V Kornilaeva Irina T Fedyakina Ali S Turgiev Andrey V Shibaev Vyacheslav S Molchanov Olga E Philippova Alexei R Khokhlov |
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| Affiliation: | 1.Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia; (E.V.K.); (V.F.L.); (G.V.K.); (I.T.F.); (A.S.T.);2.National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Russian Ministry of Health, 127473 Moscow, Russia;3.Physics Department, Moscow State University, 119991 Moscow, Russia; (A.V.S.); (V.S.M.); (A.R.K.) |
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| Abstract: | The virucidal activity of a series of cationic surfactants differing in the length and number of hydrophobic tails (at the same hydrophilic head) and the structure of the hydrophilic head (at the same length of the hydrophobic n-alkyl tail) was compared. It was shown that an increase in the length and number of hydrophobic tails, as well as the presence of a benzene ring in the surfactant molecule, enhance the virucidal activity of the surfactant against SARS-CoV-2. This may be due to the more pronounced ability of such surfactants to penetrate and destroy the phospholipid membrane of the virus. Among the cationic surfactants studied, didodecyldimethylammonium bromide was shown to be the most efficient as a disinfectant, its 50% effective concentration (EC50) being equal to 0.016 mM. Two surfactants (didodecyldimethylammonium bromide and benzalkonium chloride) can deactivate SARS-CoV-2 in as little as 5 s. |
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| Keywords: | SARS-CoV-2 COVID-19 cationic surfactants virucidal activity quaternary ammonium compounds disinfectants |
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