系统发生树构建技术综述

随着不同的分子测序技术的飞速发展使得大量的DNA分子数据不断涌现,这给生物学家提供了大量的数据使其实现重构地球上所有生命的进化树的梦想.并且,进化树的研究对于解决现代分子生物学中的许多问题都是非常关键的,如多序列比对、蛋白质结构和功能预测以及药物设计等等.但是构建进化树又是一个非常复杂的问题.因此,进化树的研究成了一个研究热点.本文介绍了进化树研究的发展、研究现状,最后在总结现有的进化树构建技术存在的问题的基础上探讨了该领域进一步的研究方向.

A Review of Phylogenetic Tree Reconstruction Technology

With the rapid development of sequencing technologies,molecular data are accumulated with unprecedented pace which enable biologists to reconstruct the tree of life of all the organisms in the world. Moreover, the use of evolutionary trees is a fundamental step in many biological problems, such as multiple .sequence alignments, protein structure and function prediction, and drug design. In this paper, we review the development and studying status of phylogeny reconstruction technology. The major limitations in phylogeny reconstruction technologies are analyzed. Then some vital aspects that may be conducted in the future investigations are discussed.