| L-抗坏血酸-2-磷酸酯镁的合成 |
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| 引用本文： | 刘毓林 石明孝. L-抗坏血酸-2-磷酸酯镁的合成[J]. 精细化工, 1997, 14(2): 19-22 |
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| 作者姓名： | 刘毓林 石明孝 |
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| 作者单位： | 浙江大学化学系 |
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| 摘 要： | Ｌ 抗坏血酸与丙酮反应生成５，６ Ｏ 异丙叉 Ｌ 抗坏血酸（ＩＡＡ），再与三氯氧磷进行磷酸化反应，脱保护合成Ｌ 抗坏血酸 ２ 磷酸酯镁。合成ＩＡＡ，采用氯化亚锡为催化剂，可得９４３％的收率。最佳磷酸化反应介质为一保持ｐＨ１２０～１２５并含高浓度吡啶（初始浓度大于２２ｍｏｌ／Ｌ）的０～１０℃的水溶液。对有关产物的结构作了表征。
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| 关 键 词： | L-抗坏血酸，5，6-O-异丙叉-L-抗坏血酸，L-抗坏血酸-2-磷酸酯镁，磷酸化 |
Synthesis of Magnesium L Ascorbate 2 phosphate |
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| Liu Yulin,Shi Mingxiao,Shen Haifeng. Synthesis of Magnesium L Ascorbate 2 phosphate[J]. Fine Chemicals, 1997, 14(2): 19-22 |
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| Authors: | Liu Yulin Shi Mingxiao Shen Haifeng |
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| Abstract: | L Ascorbic acid reacted with acetone to prepare 5,6 O isopropylidene L ascorbic acid(IAA),then phosphorylation with phosphoryl chloride and removing protective group to synthesize magnesium L ascorbate 2 phosphate.Using tin protochloride as catalyst to synthesize IAA,the yield of the product can give 94.3%.The optimum phosphorylation medium was an aqueous solution maintaining pH 12 0～12 5 at 0～10℃ and containing a high concentration of pyridine (the initial concentration above 2.2mol/L).The structures of relative products were characterized. |
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| Keywords: | L ascorbic acid 5 6 O isopropylidene L ascorbic acid magnesium L ascorbate 2 phosphate phosphorylation |
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