Protein translocation into mitochondria |
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| Authors: | K Káldi W Neupert |
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| Affiliation: | Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA. |
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| Abstract: | ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine but not that of systemic ABT-594. |
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