| 多糖免疫调节和抗肿瘤研究进展 |
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| 引用本文： | 王统一,赵兵,王玉春.多糖免疫调节和抗肿瘤研究进展[J].过程工程学报,2006,6(4):674-682. |
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| 作者姓名： | 王统一 赵兵 王玉春 |
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| 作者单位： | 1. 中国科学院过程工程研究所生化工程国家重点实验室,北京,100080;中国科学院研究生院,北京,100049
2. 中国科学院过程工程研究所生化工程国家重点实验室,北京,100080 |
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| 摘 要： | 增强免疫和抗肿瘤活性是多糖重要的生物活性. 研究表明，多糖可以通过增强免疫细胞活性、激活细胞因子的分泌、诱导生成抗体及激活补体系统等作用增强机体免疫功能. 多糖的抗肿瘤途径主要为抑制肿瘤细胞的生长、蛋白质及核酸的合成，诱导肿瘤细胞凋亡、影响癌基因的表达及改变肿瘤细胞膜的生长特性. 本文介绍了近年来多糖免疫调节和抗肿瘤研究方面的进展.
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| 关 键 词： | 多糖 免疫调节 抗肿瘤 细胞凋亡 |
| 文章编号： | 1009-606X（2006）04-0674-09 |
| 收稿时间： | 2005-10-06 |
| 修稿时间： | 2005-10-062005-12-30 |
Research Advances in Immunomodulation and Antitumor Activity of Polysaccharides |
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| WANG Tong-yi,ZHAO Bing,WANG Yu-chun.Research Advances in Immunomodulation and Antitumor Activity of Polysaccharides[J].Chinese Journal of Process Engineering,2006,6(4):674-682. |
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| Authors: | WANG Tong-yi ZHAO Bing WANG Yu-chun |
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| Affiliation: | 1. State Key Lab. Biochem. Eng., Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China; 2, Graduate University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Enhancing immunity and antiturnor activity is the important biological activity of polysaccharide. Studies showed that it enhanced immunity through improving the activity of immtmocyte, activising the secretion of cell factor, inducing the production of antibody and activising the complementary system, etc. The antitumor ways of polysaccharide mainly were inhibiting the growth of cancer cells and the synthesis of protein and nuclear acid in the cells, inducing apoptosis, affecting the expression of cancer gene and changing the growing specialities of the cancer cell membrane. In this review, research advances in the field of immunomodulation and antitumor activity ofpolysaccharides in recent years were briefly summarized and analysed. |
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| Keywords: | polysaccharide immunomodulation antiturnor apoptosis |
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