Microwave assisted fast fabrication of Fe3O4-MWCNTs nanocomposites and their application as MRI contrast agents |
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Authors: | Yuxin ChenHongchen Gu |
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Affiliation: | Nano Biomedical Research Center, School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, China |
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Abstract: | Uniform Fe3O4 nanoparticles with diameters of 3-5 nm are successfully decorated onto the external walls of multiwall carbon nanotubes (MWCNTs) by in situ high-temperature decomposition of Fe(acac)3 in polyol solution under the irradiation of microwave. With this method, reaction time of forming Fe3O4-MWCNTs nanocomposites has been significantly shortened to 15 min. The resulting Fe3O4-MWCNTs nanocomposites show superparamagnetic property at room temperature and can be remained as stable aqueous dispersion for 2 months. Longitudinal relaxivity (r1) and transverse relaxivity (r2) of the magnetic MWCNTs are 8.34 Fe mM−1 S−1 and 146 Fe mM−1 S−1 respectively. The much higher r2 value and the obvious change in the gray scale of MR images confer the Fe3O4-MWCNTs nanocomposites as potential candidates for T2-weighted MRI contrast agents. |
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Keywords: | Fe3O4 Carbon nanotubes Nanocomposites Microwave MRI contrast agents |
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