Biosynthesis of piperazic acid via N5-hydroxy-ornithine in Kutzneria spp. 744 |
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| Authors: | Neumann Christopher S Jiang Wei Heemstra John R Gontang Erin A Kolter Roberto Walsh Christopher T |
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| Affiliation: | Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. |
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| Abstract: | Which came first? We have investigated the biosynthesis of the piperazic acid (Piz) building blocks in the kutzneride family of metabolites. The flavin-dependent oxygenase KtzI was shown to convert ornithine to N(5)-OH-Orn. LC-MS/MS showed (13)C(5)-labeled versions of these two amino acids to be direct precursors of piperazic acid in vivo. |
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| Keywords: | biosynthesis enzymes metabolism natural products |
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