Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment |
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Authors: | Manuela Callari Janice R. Aldrich-Wright Paul L. de Souza Martina H. Stenzel |
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Affiliation: | 1. Nanoscale Organisation and Dynamics Group, and School of Science and Health, University of Western Sydney, Penrith, NSW 2751, Australia;2. Liverpool Hospital Clinical School, and Molecular Medicine Research Group, University of Western Sydney, Sydney, NSW 2170, Australia;3. Centre for Advanced Macromolecular Design, School of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, Australia |
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Abstract: | Metal-based anticancer drugs, in particular platinum-drugs, have been investigated for the treatment of cancer for the last 40 years. A small set of platinum-based drugs have meanwhile received FDA approval for the treatment of various cancer. Cisplatin and its relatives are currently one of the most widely used anticancer drugs. The use is however associated with significant side effects and rising drug resistance. To combat these problems, drug delivery carriers have been developed to increase the protection of the drug and increase efficacy. Metal-based drugs represent a rather unique drug delivery challenge. Most anticancer drugs are either physically encapsulated into a polymer matrix or they can be conjugated to the polymer via a degradable linker. While both pathways are possible for metal-based drugs, the conjugation to the polymer can be carried via labile or permanent ligands. In addition, the prodrug strategy using the drug in the higher oxidation state is a common approach that has been widely tested for platinum drug. The delivery of platinum drugs is now a mature field and the various conjugation techniques have been combined with a range of drug carriers including dendrimers, micelles and solid polymer nanoparticles. Hybrids of macromolecular metal complexes with inorganic nanoparticles have been tested in recent years to combine the ability to deliver the drug with imaging properties. An emerging trend is the surface decoration of the polymeric nanoparticles with targeting ligands such as folates. The advanced state of this field is evident by the fact that some macromolecular platinum drugs even advanced to the clinic. While the delivery of platinum drugs has been well explored, the delivery of other metal-based drugs based on gold, ruthenium or cobalt is still in their infancy. |
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Keywords: | A2870, ovarian cancer cells A2870cis, cisplatin resistant ovarian cancer cells A549, lung cancer cells ABRs, auditory brainstem responses AUC, area under the curve AuNP, gold nanoparticles CDDP or cisplatin, cis-diamminedichloroplatinum(II) Cis-(cha)2Pt(NO3)2, cis-bis(cyclohexylamine) dinitratoplatinum (II) CM-dex, carboxymethyl dextran CP750, [(mPEG750)(GlyPheLeu)2Et]3 nanoparticles CRC, colorectal cancer cells DCA, dichloroacetate DMF, dimethylformamide DMPC, dimyristoyl phosphatidylcholine DMPG, dimyristoyl phosphatidylgycerol DMSO, dimethyl sulfoxide DNA, deoxyribonucleic acid DOPC, dioleoyl phosphatidylcholine DOPS, dioleoyl phosphatidylserine DPPG, dipalmitoyl phosphatidyl glycerol EPR effect, enhanced permeability and retention effect FA, folic acid FDA, Food and Drug Administration HeLa, human cervical hGR, glutathione reductase HNDDSs, hybrid nanomaterial-based drug delivery systems HPMA, N-(2-Hydroxypropyl) methacrylamide HSPC, phosphatidylchlorine hTrxR, thioredoxin reductase K2PtCl4, potassium tetrachloroplatinate KP1019, trans-[RuCl4(indazole)2]indazoleH l-NDDP, aroplatin MARxTC, 1,1-di-tert-butyl 3-(x-((2,3-dimethylbut-2-enoyl)oxy)R)butane-1,1,3-tricarboxylate MABTC, MARxTC, R = butyl, x = 4 MAETC, MARxTC, R = ethyl, x = 2 MAHTC, MARxTC, R = hexyl, x = 6 MCF-7, breast cancer cell line mPEG 2000-DSPE, polyethylene glycol-distearoyl phosphatidtylethanolamine mPEG, methoxy poly(ethylene glycol) mPEG-b-PCL-b-PLL, methoxyl-poly(ethylene glycol)-b-poly(?-caprolactone)-b-poly(l-lysine) MRI, Magnetic Resonance Imaging MWCNTs, multi-walled carbon nanotubes NAMI-A, trans-[RuCl4(DMSO)(imidazole)]imidazoleH NDDP, Cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) NDs, nano-diamonds NMR, Nuclear Magnetic Resonance NTs, nano-tubes OSC-19, nude mice bearing OVCAR3, ovarian cancer cell line P(Asp), poly(l-aspartic acid) P(Glu), poly(l-glutamic acid) PAA, polyamidoamine |
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