The chemistry of tissue adhesive materials |
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Authors: | Petra J.M. Bouten Marleen Zonjee Johan Bender Simon T.K. Yauw Harry van Goor Jan C.M. van Hest Richard Hoogenboom |
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Affiliation: | 1. Radboud University Nijmegen, Institute for Molecules and Materials (IMM), Heijendaalseweg 135, 6525 AJ Nijmegen, The Netherlands;2. Supramolecular Chemistry Group, Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, 9000 Ghent, Belgium;3. GATT Technologies, Mercator III, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands;4. Radboud University Medical Center, Department of Surgery, Geert Grooteplein Zuid 10, 690, 6525 GA Nijmegen, The Netherlands |
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Abstract: | Each year millions of people sustain traumatic or surgical wounds, which require proper closure. Conventional closure techniques, including suturing and stapling, have many disadvantages. They inflict additional damage on the tissue, elicit inflammatory responses and have a relatively long application time. Especially for the more demanding wounds, where fluids or gasses are to be sealed off, these techniques are often insufficient. Therefore, a large variety of tissue adhesives, sealants and hemostatic agents have been developed. This review provides an overview of such tissue adhesive materials from a polymer chemistry perspective. The materials are divided into synthetic polymer, polysaccharide and protein based adhesives. Their specific properties and behavior are discussed and related to their clinical application. Though each type has its specific advantages, yet few have become standard in clinical practice. Biomimetic based adhesives and other novel products have shown promising results but also face specific problems. For now, the search for better adhering, stronger, easier applicable and cheaper adhesives continues and this review is intended as starting point and inspiration for these future research efforts to develop the next generation tissue adhesives. |
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Keywords: | AA, acrylic acid CS, chondroitin sulfate CSF, cerebrospinal fluid DHMPA, 2,2-bis(hydroxymethyl)-propionic acid DST, disuccinimidyl tartrate EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide FDA, U.S. Food and Drug Administration GRF, gelatin-resorcinol-formaldehyde GRFG, gelatin-resorcinol-formaldehyde&ndash glutaraldehyde HA, hyaluronic acid HA-MA, methyacrylated hyaluronic acid HDI, hexamethylene diisocyanate IEMA, 2-isocyanatoethyl methacrylate IPD, isophorone diisocyanate LCST, lower critical solution temperature MMA, methyl methacrylate MDI, diphenylmethane diisocyanate NHS, N-hydroxysuccinimide PAA, poly(acrylic acid) PBS, phosphate buffered saline PCL, poly(?-caprolactone) PDMS, poly(dimethyl siloxane) PEG, poly(ethylene glycol) PGA, poly(glycolic acid) PGLSA, poly(glycerol succinic acid) PGSA, poly(glycerol sebacate acrylate) PLA, poly(lactic acid) PLGA, poly(lactic-co-glycolic acid) Plu, pluronic (PEG&ndash PPO&ndash PEG) Plu-SH, thiol functionalized pluronic PPO, poly(propylene oxide) PS, polystyrene PTMEG, poly(tetramethylene ether glycol) PTMC, poly(trimethylene carbonate) PVP, poly(N-vinylpyrrolidone) |
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