首页 | 本学科首页   官方微博 | 高级检索  
     


Dendrimer as nanocarrier for drug delivery
Authors:Prashant Kesharwani  Keerti Jain  Narendra Kumar Jain
Affiliation:Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (MP) 470 003, India
Abstract:Dendrimers are novel three dimensional, hyperbranched globular nanopolymeric architectures. Attractive features like nanoscopic size, narrow polydispersity index, excellent control over molecular structure, availability of multiple functional groups at the periphery and cavities in the interior distinguish them amongst the available polymers. Applications of dendrimers in a large variety of fields have been explored. Drug delivery scientists are especially enthusiastic about possible utility of dendrimers as drug delivery tool. Terminal functionalities provide a platform for conjugation of the drug and targeting moieties. In addition, these peripheral functional groups can be employed to tailor-make the properties of dendrimers, enhancing their versatility. The present review highlights the contribution of dendrimers in the field of nanotechnology with intent to aid the researchers in exploring dendrimers in the field of drug delivery.
Keywords:AFM, atomic force microscopy   BHA, benzhydrylamine   BSA, bovine serum albumin   CE, capillary electrophoresis   CNTs, carbon nanotubes   CPDs, cationic phosphorus-containing dendrimers   CZE, capillary zone electrophoresis   DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine   DOX, doxorubicin   DPA, 2,4-dichlorophenoxyacetic acid   DSC, differential scanning calorimetry   DTPA, diethylene triamine pentaacetic acid   EDTA, ethylenediamine tetraacetic acid   ESI, electrospray ionization   ESI-MS, electrospray ionization-mass spectrometry   FA, folic acid   FAB-MS, fast-atom bombardment-mass spectrometry   FITC, fluorescein isothiocynate   FRET, fluorescence resonance energy transfer   FT-ICR MS, fourier transform ion cyclotron resonance mass spectrometry   FT-IR, fourier transform infrared spectroscopy   GFP, green fluorescence protein   GOx, glucose oxidase   Hb, hemoglobin   HCT, haematocrit   HEPES, (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid)   HPLC, high performance liquid chromatography   HRP, horseradish peroxide   HSV, herpes simplex virus   LC, liquid crystalline   LDH, lactate dehydrogenase   MALDI-TOF MS, matrix assisted laser desorption ionization-time of flight mass spectrometry   MAP, multiple antigen peptides   MPEG, methoxy polyethylene glycol   MRI, magnetic resonance imaging   MS, mass spectrometry   MTD, maximum tolerated dose   MTX, methotrexate   NMR, nuclear magnetic resonances   NSAIDs, non steroidal anti-inflammatory drugs   OS, organosilicon   PAGE, polyacrylamide gel electrophoresis   PAMAM, polyamidoamine   PAMAMOS, PAMAM-organosilicon dendrimers   PAMAM-SAHs, PAMAM succinamic acid dendrimers   PEI, polyethylenimine   PPI, poly (propylene imine)   PSMA, prostate-specific membrane antigen   PTX, paclitaxel   PVP, polyvinyl-pyrrolidone   RES, reticuloendothelial system   RNase, ribonuclease   RST, repetitive synthesis technique   SANS, small-angle neutron scattering   SAXS, small-angle X-ray scattering   SEC, size exclusion chromatography   siRNA, small interfering RNA   TEER, transepithelial electrical resistance   TEM, transmission electron microscopy   TGA, thermogravimetric analysis   TLR4, Toll-like receptor 4   UPLC, ultra performance liquid chromatography   WBCs, white blood corpuscles   XRD, X-ray diffraction
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号