Dendrimer as nanocarrier for drug delivery |
| |
Authors: | Prashant Kesharwani Keerti Jain Narendra Kumar Jain |
| |
Affiliation: | Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (MP) 470 003, India |
| |
Abstract: | Dendrimers are novel three dimensional, hyperbranched globular nanopolymeric architectures. Attractive features like nanoscopic size, narrow polydispersity index, excellent control over molecular structure, availability of multiple functional groups at the periphery and cavities in the interior distinguish them amongst the available polymers. Applications of dendrimers in a large variety of fields have been explored. Drug delivery scientists are especially enthusiastic about possible utility of dendrimers as drug delivery tool. Terminal functionalities provide a platform for conjugation of the drug and targeting moieties. In addition, these peripheral functional groups can be employed to tailor-make the properties of dendrimers, enhancing their versatility. The present review highlights the contribution of dendrimers in the field of nanotechnology with intent to aid the researchers in exploring dendrimers in the field of drug delivery. |
| |
Keywords: | AFM, atomic force microscopy BHA, benzhydrylamine BSA, bovine serum albumin CE, capillary electrophoresis CNTs, carbon nanotubes CPDs, cationic phosphorus-containing dendrimers CZE, capillary zone electrophoresis DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine DOX, doxorubicin DPA, 2,4-dichlorophenoxyacetic acid DSC, differential scanning calorimetry DTPA, diethylene triamine pentaacetic acid EDTA, ethylenediamine tetraacetic acid ESI, electrospray ionization ESI-MS, electrospray ionization-mass spectrometry FA, folic acid FAB-MS, fast-atom bombardment-mass spectrometry FITC, fluorescein isothiocynate FRET, fluorescence resonance energy transfer FT-ICR MS, fourier transform ion cyclotron resonance mass spectrometry FT-IR, fourier transform infrared spectroscopy GFP, green fluorescence protein GOx, glucose oxidase Hb, hemoglobin HCT, haematocrit HEPES, (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) HPLC, high performance liquid chromatography HRP, horseradish peroxide HSV, herpes simplex virus LC, liquid crystalline LDH, lactate dehydrogenase MALDI-TOF MS, matrix assisted laser desorption ionization-time of flight mass spectrometry MAP, multiple antigen peptides MPEG, methoxy polyethylene glycol MRI, magnetic resonance imaging MS, mass spectrometry MTD, maximum tolerated dose MTX, methotrexate NMR, nuclear magnetic resonances NSAIDs, non steroidal anti-inflammatory drugs OS, organosilicon PAGE, polyacrylamide gel electrophoresis PAMAM, polyamidoamine PAMAMOS, PAMAM-organosilicon dendrimers PAMAM-SAHs, PAMAM succinamic acid dendrimers PEI, polyethylenimine PPI, poly (propylene imine) PSMA, prostate-specific membrane antigen PTX, paclitaxel PVP, polyvinyl-pyrrolidone RES, reticuloendothelial system RNase, ribonuclease RST, repetitive synthesis technique SANS, small-angle neutron scattering SAXS, small-angle X-ray scattering SEC, size exclusion chromatography siRNA, small interfering RNA TEER, transepithelial electrical resistance TEM, transmission electron microscopy TGA, thermogravimetric analysis TLR4, Toll-like receptor 4 UPLC, ultra performance liquid chromatography WBCs, white blood corpuscles XRD, X-ray diffraction |
本文献已被 ScienceDirect 等数据库收录! |
|