Toward the biomimetic implant surface: Biopolymers on titanium-based implants for bone regeneration |
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| Authors: | Ricardo Tejero Eduardo Anitua Gorka Orive |
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| Affiliation: | 1. Department of Biochemistry and Molecular Biology, University of the Basque Country, 48940 Leioa, Spain;2. BTI I+D, Leonardo da Vinci 14B, 01510 Vitoria, Spain;3. Private Practice in Implantology and Oral Rehabilitation, José Mª Cagigal 19, 01007 Vitoria, Spain;4. Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain;5. Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, SLFPB-EHU, 01006 Vitoria-Gasteiz, Spain |
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| Abstract: | Replacing malfunctioning tissues with titanium-based implants has become a widespread practice spurred by population aging. Advances in biomaterials, technology and implantation protocols have led to increasing expectations on the applicability and durability of implants. The field has recently moved from a bioinert to a bioactive paradigm due to surface modifications that trigger specific responses on the surrounding tissues. Biopolymeric surface coatings have taken up a central role in these developments. The use of these and other biomimetic strategies on implants provides greater control over material–cell interactions and it is aimed at improving long-term clinical results by replicating some of the structures and mechanisms of living tissues. This review summarizes the state of the art of biomimetic implants and discusses the main directions and challenges of this field toward a more predictable and successful implant osseointegration. |
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| Keywords: | @w, at week ADP, Adenosine DiPhosphate AE, Acid Etched ALP, Alkaline Phosphatase APTES, (Aminopropyl)Triethoxysilane ATP, Adenosin TriPhosphate BIC, Bone-Implant Contact BMP, Bone Morphogenetic Protein BSP, Bone Sialoprotein Ca, Calcium CaP, Calcium Phosphate CCL2, Chemokine Ligand 2 CD, Cluster of Differentiation CDI, Carbonyldiimidazole CoCr, Cobalt-Chrome Col, Collagen CS, Chondroitin Sulfate CXCR, Chemokine Receptor Cy5, Cyanine fluorescent dye (Excitation: 650 nm, Emission: 670 nm) DEPPA, 3-(Diethoxy-Phosphoryl)propionicAcid EC, Endothelial Cell ECAD, Electrochemically Assisted Deposition ECM, ExtraCellular Matrix EDC, Ethyl(dimethylaminopropyl) Carbodiimide Eph, Ephrin Receptor FB, Fibroblast FG, Fibrinogen FGF, Fibroblastic Growth Factor FITC, Fluorescein Isothiocyanate FN, Fibronectin GAG, Glycosaminoglycan GDF, Growth and Differentiation Factor GF, Growth Factor Gly, Glycine GP, Glycoprotein GRGDSPC, Gly-Arg-Gly-Asp-Ser-Pro-Cys peptide sequence HA, Hyaluronic Acid HAP, Hydroxyapatite HGF, Hepatocyte Growth Factor HIF, Hypoxia-inducible Factor HVP, Human Vitronectin Precursor Hyl, Hydroxylysine Hyp, Hydroxyproline IGF, Insulin Growth Factor IL, Interleukin IPN, Interpenetrating Network ISQ, Initial Stability Quotient LN, Laminin M-CSF, Macrophage Colony Stimulating Factor Mach Ti, Titanium &ldquo as machined&rdquo MCP, Monocyte Chemotactic Protein MMP, Matrix Metalloprotease MSC, Mesenchymal Stem Cell NCP, Non-Collagenous Protein NFκβ, Nuclear Factor Kappa Beta NHS, N-Hydroxysuccinimide NPC, 4-Nitrophenil-Chloroformate OB, Osteoblast OC, Osteoclast OCa, Osteocalcin OCP, Octacalcium Phosphate ON, Osteonectin OPG, Osteoprotegerin OPN, Osteopontin Ox, Oxidized p(OEGMA), Poly Oligo(Ethylene Glycol Methacrylate) PA, Peri-Apatite PAF, Platelet Activation Factor PCCS, Platelet Concentrate Collection System PCS, Platelet Collection System PDGF, Platelet Derived Growth Factor PEF, Platelet Enrichment Factor PEG, Poly(Ethylene Glycol) PG, Proteoglycan PHSRN, Pro&ndash His&ndash Ser&ndash Arg&ndash Asn peptide sequence PLT, Platelet PMN, Polymorphonuclear leukocytes PRGF, Plasma Rich in Growth Factors Pro, Proline PrP, Platelet rich Plasma PS, Phosphoserine PTH, Parathyroid Hormone PVD, Plasma Vapor Deposition RANK, Receptor Activator of Nuclear Factor rBC, red Blood Cells RGD, Arg-Lys-Asp peptide sequence RGDC, Arg-Lys-Asp-Cys peptide sequence SB, Sand Blasted SBF, Simulated Body Fluid SDF, Stromal Cell-Derived Factor SMP, N-succimidyl-3-maleimidopropionate SMPB, sulfo-Succinylimidyl-4-(p-Maleimido Phenyl Butyrate)) TCP, TriCalcium Phosphate TGF-ß , Transforming Growth Factor ß Ti, Titanium TIMP, Tissue Inhibitors of Metalloproteinases TNF, Tumor Necrosis Factor VEGF, Vascular Endothelial Growth Factor VN, Vitronectin vWF, von Willebrand Factor wBC, white Blood Cells μCT, Micro-Computer Tomography |
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