| 乙型肝炎疫苗-卡介苗联合疫苗在动物中的免疫应答 |
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| 引用本文： | 杨丽华,王志,赵小琳,杨彤,于爱东,刘艾红,金立杰.乙型肝炎疫苗-卡介苗联合疫苗在动物中的免疫应答[J].粉末涂料与涂装,2006,19(4):378-380. |
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| 作者姓名： | 杨丽华 王志 赵小琳 杨彤 于爱东 刘艾红 金立杰 |
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| 作者单位： | 长春生物制品研究所疫苗五室 长春130062 |
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| 基金项目： | 吉林省科技发展计划项目(20050402-1). |
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| 摘 要： | 目的评价乙型肝炎疫苗-卡介苗联合疫苗的免疫应答。方法用联合疫苗及其单价疫苗分别免疫豚鼠和BALB/c小鼠,检测两种疫苗的免疫应答。结果联合疫苗与卡介苗豚鼠皮肤PPD反应直径数值相近(P>0·05),联合疫苗与乙肝疫苗免疫小鼠血清乙肝抗体滴度差异无显著意义(P>0·05);联合疫苗免疫小鼠淋巴细胞转化刺激指数、IL-2含量均高于单价疫苗,差异有显著意义(P<0·001)。结论乙型肝炎疫苗-卡介苗联合疫苗能有效地诱导实验动物的体液免疫和细胞免疫。
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| 关 键 词： | 乙型肝炎疫苗 卡介苗 联合疫苗 免疫应答 |
| 收稿时间： | 2005-06-27 |
| 修稿时间： | 2005年6月27日 |
Immune Response Induced by HB-BCG Combined Vaccine in Animals |
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| YANG Li-hua, WANG Zhi, ZHAO Xiao-lin, et al.Immune Response Induced by HB-BCG Combined Vaccine in Animals[J].Chinese Journal of Biologicals,2006,19(4):378-380. |
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| Authors: | YANG Li-hua WANG Zhi ZHAO Xiao-lin |
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| Affiliation: | Changchun Institute of Biological Products, Changchun 130062, China |
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| Abstract: | Objective To evaluate the immune response induced by HB-BCG combined vaccine.Methods Immunize guinea pigs and BALB/c mice with hepatitis B(HB) vaccine,BCG vaccine and HB-BCG combined vaccine separately and determine the immune responses induced in the animals.Results The skin reaction diameters in PPD test of guinea pigs immunized with HB-BCG combined vaccine showed no significant difference from with BCG vaccine(P>0.05).No significant difference was observed between the serum HB antibody titers of mice immunized with HB-BCG combined vaccine and HB vaccine(P>0.05).The lymphocyte transformation stimulating index and IL-2 level induced by HB-BCG combined vaccine were significantly higher than those induced by monovalent HB or BCG vaccine(P<0.001).Conclusion HB-BCG combined vaccine effectively induced both humoral and cellular immune responses in animals. |
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| Keywords: | Hepatitis vaccine BCG Combined vaccine Immune response |
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