| 噻唑衍生物的合成研究进展 |
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| 引用本文： | 王银柱,熊国宣,张志宾,雷亮. 噻唑衍生物的合成研究进展[J]. 材料导报, 2012, 26(1): 71-74,78 |
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| 作者姓名： | 王银柱 熊国宣 张志宾 雷亮 |
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| 作者单位： | 1. 东华理工大学放射性地质与勘探技术国防重点学科实验室,抚州,344000
2. 东华理工大学核资源与环境教育部重点实验室,南昌,330013 |
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| 基金项目： | 江西省自然科学基金，放射性地质与勘探技术国防重点学科实验室开放基金，江西省教育厅科学基金，东华理工大学研究生创新基金 |
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| 摘 要： | 噻唑类化合物具有广泛的生物活性,已成为国内外学者研究的重要课题。阐述了噻唑类化合物各种合成方法,有Hantzsch合成法、高碘试剂合成法、异硫氰酸酯合成法、固相树脂合成法、二羰基化合物合成法、芳醛与胺缩合氧化法、负载试剂合成法等,并指出了其中一些合成方法的优缺点。最后对噻唑化合物的研究方向作了简要的展望。
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| 关 键 词： | 生物活性 噻唑衍生物 合成 研究进展 |
Progress on the Synthesis of the Thiazole Derivatives |
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| WANG Yinzhu , XIONG Guoxuan , ZHANG Zhibin , LEI Liang. Progress on the Synthesis of the Thiazole Derivatives[J]. Materials Review, 2012, 26(1): 71-74,78 |
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| Authors: | WANG Yinzhu XIONG Guoxuan ZHANG Zhibin LEI Liang |
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| Affiliation: | (Key Laboratory of Radioactive Geology and Exploration Technology Fundamental Science for National Defense, East China Institute of Technology,Fuzhou 344000;Key Laboratory of Nuclear Resources and Environment, Ministry of Education,East China Institute of Technology,Nanchang 330013) |
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| Abstract: | The thiazole derivatives possess extensive biological activity and have been an important issue studied by the domestic and overseas researchers.The research progress on the synthesis of the thiazole derivatives is stated,such as Hantzsch,the reagents of periodide,isothiocyanate,solid resin,dicarbonyl compound,oxidizing reaction of aromatic aldehyde with amine,loaded reagent,etc.The advantage and disadvantage of some methods are pointed out.In the end,the prospect of their research orientations are forecasted. |
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| Keywords: | bioactivity the thiazole derivatives synthesis progress |
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