A glassy carbon supported bilayer lipid-like membrane of 5,5-ditetradecyl-2-(2-trimethyl-ammonioethyl)-1,3-dioxane bromide for electrochemical sensing of epinephrine |
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Authors: | Jingming Gong |
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Affiliation: | Department of Chemistry, University of Science and Technology of China, 96 Jinzhai, Hefei 230026, PR China |
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Abstract: | A self-assembled bilayer lipid-like membrane (BLM) supported on glassy carbon electrode (GCE) was fabricated using 5,5-ditetradecyl-2-(2-trimethyl-ammonioethyl)-1,3-dioxane bromide (DTDB) for epinephrine (EP) determination in the presence of ascorbic acid (AA). This modified electrode (DTDB/GCE) has strong membrane adsorption accumulation and electrocatalytic ability toward EP and AA. The oxidation of EP was controlled by double step adsorption accumulation process of the DTDB-BLM. The parameters of fitted Langmuir isotherm Γmax, BADS, and ΔGADS values were determined as 1.0×10−11 mol cm−2, 2.04×106 dm3 mol−1, and −45.17 kJ mol−1 for the fist step for EP concentration less than 1 mM, and 4.92×10−11 mol cm−2, 7.35×104 dm3 mol−1, and −37.1 kJ mol−1 for the second step for EP concentration higher than 1 μM. The DPV peaks for EP and AA oxidations were appeared at 0.220 and 0.085 V versus SCE, respectively, allowing the determination of EP in the presence of high concentration of AA. The advantage of DTDB-BLM was demonstrated experimentally in comparison with other three BLMs, and attributed to the dioxane group as well as the suitable length of the carbon chain of DTDB molecule. The current response of the DTDB/GCE was fast and reproducible, suitable for the electrochemical sensing in flow-injection systems. A linear range of 1×10−8 to 1×10−4 M EP was preliminary obtained using a simple setup. |
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Keywords: | Bilayer lipid-like membrane Epinephrine Electrocatalysis Membrane accumulation 5 5-Ditetradecyl-2-(2-trimethyl-ammonioethyl)-1 3-dioxane bromide |
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