N-溴丁二酰亚胺／吡啶氧化合成己二酰基双偶氮化合物

以己二酰二氯和不同取代基的苯肼合成了N,N'-二芳基己二酰二肼类中间体,然后在N-溴丁二酰亚胺(NBS)／吡啶氧化体系下室温合成了8种己二酰基双偶氮化合物。第一步反应条件为:n(己二酰二氯):n(取代苯肼)=1:2,反应温度0-5℃,反应时间4 h,收率80%-93％;第二步反应条件为:n(N,N’-二芳基己二酰二肼):n(NBs／吡啶)=1:2,氧化反应时间0．5-1．0 h,收率80%-94%。并用元素分析、IR、1H NMR对合成的中间产物及目标化合物进行了表征。

SYNTHESIS OF ADIPYL BIS-AZO COMPOUNDS USING N-BROMOSUCCINIMIDE/PYRIDINE

Eight kinds of adipyl bis-azo compounds were synthesized through a two-step process. First, at 0 - 5℃, n(adipic chloride ) : n(substituted benzyldiazane) =1 : 2, the intermediate N, N'-diaryl adipyl dihydrazide was synthesized in 4 h by using adipic chloride and substituted benzyldiazane as raw materials with yields of 80%- 93%. Then, under the conditions of n(N, N'-diaryl adipyl dihydrazide) : n(N-bromosuccinimide/pyridine) = 1 : 2, the final product was synthesized from 30 min to 1 h with the yields of 80%-93%. The products were characterized and confirmed by elemental a-nalysis, IR, 1 H NMR, etc.