黑米花色苷提取物对ApoE基因缺陷小鼠动脉粥样硬化晚期斑块的影响

研究黑米花色苷提取物对ApoE基因缺陷小鼠动脉粥样硬化晚期斑块的影响。将30周龄的ApoE基因缺陷小鼠分为三组,两实验组分别在小鼠正常饲料中添加黑米花色苷提取物和药物辛伐他汀粉末,空白对照组喂饲小鼠正常饲料。结果表明,黑米花色苷提取物能显著降低小鼠血清的总胆固醇(TC)、总甘油三酯(TG)以及低密度脂蛋白胆固醇(LDL-C)水平,同时减少无名动脉处的斑块面积,降低斑块中基质金属蛋白酶-1(MMP-1)的含量。由此本研究可得出如下结论:黑米花色苷提取物能抑制小鼠动脉粥样硬化晚期斑块的进一步的发展。

Effects of Black Rice Anthocyanin-rich Extract on Advanced Atherosclerotic Plaque in ApoE Deficient Mice

This paper studied the effects of anthocyanin-rich extract from black rice on advanced plaques in ApoE deficientmice. ApoE deficient mice of 30 weeks of age were randomly divided into 3 groups: mice in two experimental groups were fedchow diets supplemented with black rice anthocyanin-rich extract and simvastatin seperately, while control group was fed anormal chow diet. Lipid profile of serum, plaque area and matrix metalloproteinase content in the innominate artery were assayed.Results showed that the anthocyanin-rich extract lowers TC, TG and LDL-C levels in serum, and decreases plaque area andMMP content in the innominate artery of mice. Conclusion: anthocyanin-rich extract can inhibit further development of advancedplaque in ApoE deficient mice.