Chiral lewis acid-catalyzed enantioselective michael reactions in water |
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| Authors: | Shū Kobayashi Kentaro Kakumoto Yuichiro Mori Kei Manabe |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan and Science and Technology Corporation (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
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| Abstract: | Asymmetric Michael reactions of ß-ketoesters with enones were effectively catalyzed by complexes of silver salts and BINAP derivatives in water. The reactions have proved to give Michael adducts in high yields with high enantioselectivities. These reactions are the first example of Lewis acid-catalyzed asymmetric Michael reactions in water. |
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