Palladium(0)-Catalyzed Allylation Reaction with Dimethyl 2-fluoromalonate |
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| Authors: | Tomoko Kawasaki Tomoya Kitazume |
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| Affiliation: | Department of Bioengineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226–8501, Japan |
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| Abstract: | The palladium(0)-catalyzed allylation reaction of dimethyl 2-fluoromalonate with allylic carbonates proceeds smoothly under neutral conditions to give the SN2 allylation product. However, using the nucleophile NaCF(CO2Et)2 under basic conditions increased the chemical yield. Moreover, the SN2′ allylation product was increased up to 75% yield. |
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