The effect of activated macrophage products on neurite growth in an organotypic culture of chick embryo sensory ganglia] |
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Authors: | NI Chalisova VB Okulov GN Akoev AO Danilov SG Zubova MI Liudyno VA Penniia?nen |
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Affiliation: | Institute of Physiology, Russian Academy of Sciences, St. Petersburg. |
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Abstract: | Murine peritoneal macrophages, activated by BCG vaccine, and human peripheral blood monocytes, activated by lipopolysaccharides, exerted neurite stimulating or neurite inhibiting effects in various periods of activation. The supernatants of these preparations were active in organotypic culture of chick embryo dorsal root ganglia. The inhibition of neurite growth on the 1st day of cultivation was followed by the neurite-stimulating effect. The fluctuation of neurite-inhibition and neurite-stimulation effect of macrophage supernatants suggest the availability of certain changes in cytokine composition in different periods of macrophage activation. |
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