Nucleocytoplasmic transport: driving and directing transport |
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| Authors: | CN Cole CM Hammell |
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| Affiliation: | Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. charles.cole@dartmouth.edu |
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| Abstract: | Nucleocytoplasmic transport involves assembly and movement across the nuclear envelope of cargo-receptor complexes that interact with the small GTPase Ran. The asymmetric distribution of Ran regulator proteins, RanGAP1 and RCC1, provides the driving force and directionality for nuclear transport. |
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