A transdermal diltiazem hydrochloride delivery device using multi-walled carbon nanotube/poly(vinyl alcohol) composites |
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| Affiliation: | 1. Department of Orthopaedic Surgery (MC 844), University of Illinois at Chicago, Chicago, Illinois;2. Department of Orthopaedic Surgery (MC 3079), University of Chicago, Chicago, Illinois;3. Illinois Bone and Joint Institute, Morton Grove, Illinois;1. College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang 471022, China;2. Department of Chemistry, and Key Laboratory of Guizhou High Performance Computational Chemistry, Guizhou University, Guiyang 550025, China;1. Laboratory of Cytogenetics, West Pomeranian University of Technology, Szczecin, Janickiego 29, 71-270 Szczecin Poland;2. Department of Environmental and Chemical Engineering, West Pomeranian University of Technology, Szczecin, Piastow Avenue 45, 70-311 Szczecin, Poland;3. Institute of Chemical Engineering and Environmental Protection Process, West Pomeranian University of Technology, Szczecin, Piastow Avenue 42, 71-065 Szczecin, Poland;1. Department of Orthopaedic Surgery, Juntendo University Urayasu Hospital, Japan;2. Department of Orthopaedic Surgery, Juntendo University, Japan;1. University of Bucharest, Magurele, Ilfov, Romania;2. National Institute for Lasers, Plasma, and Radiation Physics, Magurele, Ilfov, Romania;3. Politehnica University of Bucharest, Bucharest, Romania;4. Institute of Biochemistry, Romanian Academy, Bucharest, Romania |
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| Abstract: | Membranes with high strength and elasticity are of great demand in patch therapy. Similar membranes have been developed by combining carboxy-functionalized multiwalled carbon nanotube (c-MWCNT) with different poly(vinyl alcohol) (PVA) as potential diltiazem delivery device through aqueous mixing. High molecular weight PVA (PVAH) produced stronger interaction with c-MWCNT than low molecular weight PVA (PVAL) preferably at low concentration. Positive changes in favor of PVAH in infrared and solid state 13C nuclear magnetic resonance spectroscopy, wide angle X-ray scattering, thermal stability, morphology and dry and wet mechanical properties clearly demonstrate that. Fibrillar c-MWCNT array at 1 wt.% in PVAH (PVAH/1) has drastically improved PVA crystalline cell dimension, tensile strength (201%) and elongation (196%) than neat PVAH whereas the similar improvement is much less (100% and 185%) in PVAL (PVAL/1) due to globular morphology. Instead, c-MWCNT performed better at 0.5 wt.% in PVAL (PVAL/0.5). The kinetic data reflects better encapsulation and slower release by PVAH (5.87%) than PVAL (10.17%) due to greater interfacial interaction. |
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