Biomimetic synthesis and characterization of carbon nanofiber/hydroxyapatite composite scaffolds |
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| Affiliation: | 1. Stomatological Hospital of Chongqing Medical University, Chongqing 401147, China;2. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China;3. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China;4. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China;5. Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;6. State Key Laboratory of Military Stomotology, Department of General Dentistry and Emergency, Shool of Stomatogy, The Fourth Military Medical University, Xi''an 710032, China;7. School of Stomatology, Tianjin Medical University, Tianjin 300070, China;1. Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea;2. Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea;3. Department of Convergence Technology Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea;1. Department of Materials Science and Engineering, Institute of Materials Science, University of Connecticut, 97 North Eagleville Rd., Storrs, CT 06269, USA;2. Department of Chemical and Biomolecular Engineering, University of Connecticut, 191 Auditorium Rd., Storrs, CT 06269, USA |
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| Abstract: | Three dimensional electrospun carbon nanofiber (CNF)/hydroxyapatite (HAp) composites were biomimetically synthesized in simulated body fluid (SBF). The CNFs with diameter of ～250 nm were first fabricated from electrospun polyacrylonitrile precursor nanofibers by stabilization at 280 °C for 2 h, followed by carbonization at 1200 °C. The morphology, structure and water contact angle (WCA) of the CNFs and CNF/HAp composites were characterized. The pristine CNFs were hydrophobic with a WCA of 139.6°, resulting in the HAp growth only on the very outer layer fibers of the CNF mat. Treatment in NaOH aq. solutions introduced carboxylic groups onto the CNFs surfaces, and hence making the CNFs hydrophilic. In the SBF, the surface activated CNFs bonded with Ca2+ to form nuclei, which then easily induced the growth of HAp crystals on the CNFs throughout the CNF mat. The fracture strength of the CNF/HAp composite with a CNF content of 41.3% reached 67.3 MPa. Such CNF/HAp composites with strong interfacial bondings and high mechanical strength can be potentially useful in the field of bone tissue engineering. |
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