| 抗肿瘤新药甲啶铂的合成工艺研究 |
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| 引用本文： | 王庆琨,普绍平,何 键,刘凉萌,廖云星,晋 杰.抗肿瘤新药甲啶铂的合成工艺研究[J].贵金属,2013,34(4):37-39. |
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| 作者姓名： | 王庆琨 普绍平 何 键 刘凉萌 廖云星 晋 杰 |
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| 作者单位： | 昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106;昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106;昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106;昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106;昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106;昆明贵研药业有限公司 云南省铂族金属抗肿瘤药物工程技术研究中心，昆明 650106 |
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| 基金项目： | 云南省科技计划资助项目(2010DH021)。 |
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| 摘 要： | 为合成抗肿瘤药物甲啶铂，采用醋酸铵与K2PtCl4反应生成KPt(NH3)Cl3]，再先后与碘化钾、2-甲基吡啶、硝酸银、氯化钾反应生成甲啶铂。采用元素分析、质谱、核磁共振氢谱和红外光谱对其结构进行了表征。结果显示合成的化合物与理论一致，产率约为40%，可为甲啶铂的合成提供一条新的工艺路线。
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| 关 键 词： | 有机化学 铂配合物 甲啶铂 合成 |
| 收稿时间： | 2013/2/22 0:00:00 |
A New Synthetic Method of Picoplatin, An Antitumor Drug |
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| WANG Qingkun,PU Shaoping,HE Jian,LIU Liangmeng,LIAO Yunxing and JIN Jie.A New Synthetic Method of Picoplatin, An Antitumor Drug[J].Precious Metals,2013,34(4):37-39. |
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| Authors: | WANG Qingkun PU Shaoping HE Jian LIU Liangmeng LIAO Yunxing and JIN Jie |
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| Affiliation: | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China |
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| Abstract: | To synthesize a platinum-based anti-tumor drug picoplatin, the key intermediate KPt(NH3)Cl3] , synthesized from ammonium acetate and K2PtCl4 was subsequently reacted with KI, 2-picoline, AgNO3 and KCl to give the target compound. The structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR. The results showed that its structure was consistent with the title compound and the yield was about 40%. This provides a new process for the synthesis of picoplatin. |
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| Keywords: | organic chemistry platinum complex picoplatin synthesis |
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