| 3-醛基吲哚-7-甲酸的合成 |
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| 引用本文： | 葛裕华,吴亚明,薛忠俊. 3-醛基吲哚-7-甲酸的合成[J]. 化学试剂, 2006, 28(3): 181-182 |
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| 作者姓名： | 葛裕华 吴亚明 薛忠俊 |
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| 作者单位： | 东南大学,化学化工系,江苏,南京,210096 |
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| 摘 要： | 以3-甲基-2-硝基苯甲酸为原料,用MeOH/H2SO4酯化先制得3-甲基-2-硝基苯甲酸甲酯(2),化合物2与DMFDMA缩合后经Fe/HOAc还原得到吲哚-7-甲酸甲酯(4),最后化合物4与POCl3/DMF通过Vilsmeier反应合成了标题化合物,总收率53%。产物的结构经1HNMRI、R和MS得到确证。
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| 关 键 词： | 3-醛基吲哚-7-甲酸 吲哚-7-甲酸甲酯 合成 |
| 文章编号： | 0258-3283（2006）03-0181-02 |
| 收稿时间： | 2005-05-02 |
| 修稿时间： | 2005-05-02 |
Synthesis of 3-formylindole-7-carboxylic acid |
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| GE Yu-hua,WU Ya-ming,XUE Zhong-jun. Synthesis of 3-formylindole-7-carboxylic acid[J]. Chemical Reagents, 2006, 28(3): 181-182 |
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| Authors: | GE Yu-hua WU Ya-ming XUE Zhong-jun |
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| Affiliation: | Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096,China |
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| Abstract: | 3-Formylindole-7-carboxylic acid(1) was synthesized from 3-methyl-2-nitrobenzoic acid as raw material by esterification with MeOH/H_2SO_4,condensation with DMFDMA,reduction with Fe/HOAc and Vilsmeier-Hacck reaction with POCl_3/DMF in an overall yield of 53%.The structure of 1 was confirmed by(()~1HNMR),IR and MS. |
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| Keywords: | 3-formylindole-7-carboxylic acid methyl indole-7carboxylate synthesis |
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