鲜红斑痣光动力治疗的模型仿真初步研究

为了研究光敏剂特性对光动力疗法(PDT)治疗鲜红斑痣(PWS)疗效的影响，帮助临床采取有效的治疗方案，建立了光动力治疗鲜红斑痣的数学模型。建立了卟啉类光敏剂受光激发产生单线态氧的数学模型以及光敏剂自身漂白过程和组织中扩散过程的数学模型，以国产光敏剂血啉甲醚(HMME)的实验数据为例，用蒙特卡罗方法仿真组织中的光分布，应用建立的单线态氧产生过程的数学模型，仿真光动力治疗鲜红斑痣过程中，组织内单线态氧产量的分布。对比不同的光敏剂漂白速度对组织中单线态氧产量的影响，发现漂白速率越快，破坏血管的同时对表皮和真皮组织的保护作用越好。这些结果为光动力疗法治疗鲜红斑痣的临床应用提供了具有针对性的指导。

Modeling and Simulation of the Acting Factors on Vascular Selectivity of Photodynamic Therapy

Photodynamic therapy (PDT) based on topical application of photosensitizers has been under development over last years. Typical application of photodynamic therapy is treatment of port wine stain (PWS). The dosimetry for topically administered photosensitizers must take an inhomogeneous drug distribution into account together with the conventional parameters such as optical scattering, absorption, and photobleaching. To study the acting factors on vascular selectivity of photodynamic therapy, the mathematic modeling of vascular selectivity of photodynamic therapy was achieved. The singlet oxygen distributions in tissue were simulated with Monte Carlo simulated light distribution. Effect of different photobleaching velocity was discussed. The simulated results indicated that faster photobleaching velocity was helpful to protect the epidermis and dermis. These results were useful for the application of photodynamic therapy in treatment of port wine stain.