| 硫酸头孢喹肟的合成 |
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| 引用本文： | 李常青,闫祥华,薛俊娟,马凤龙,乔彦良. 硫酸头孢喹肟的合成[J]. 应用化工, 2008, 37(2): 231-232 |
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| 作者姓名： | 李常青 闫祥华 薛俊娟 马凤龙 乔彦良 |
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| 作者单位： | 山东信得科技股份有限公司,山东,青岛,266061 |
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| 摘 要： | 研究第四代头孢类抗生素硫酸头孢喹肟的合成工艺。以7-氨基头孢烷酸(7-ACA)为原料,在三甲基碘硅烷的作用下与5,6,7,8-四氢喹啉缩合,得到中间体7-氨基头孢喹肟(7-ACQ),7-ACQ直接与AE活性酯反应,得到头孢喹肟硫酸盐,总收率51.9%。用元素分析,IR与1H NMR对其结构进行了鉴定。该合成路线适合工业化生产。
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| 关 键 词： | 头孢喹肟 5,6,7,8-四氢喹啉 7-ACA 合成 |
| 文章编号： | 1671-3206（2008）02-0231-02 |
| 收稿时间： | 2007-11-20 |
| 修稿时间： | 2007-11-20 |
Synthesis of cefquinome sulfate |
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| LI Chang-qing,YAN Xiang-hua,XUE Jun-juan,MA Feng-long,QIAO Yan-liang. Synthesis of cefquinome sulfate[J]. Applied chemical industry, 2008, 37(2): 231-232 |
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| Authors: | LI Chang-qing YAN Xiang-hua XUE Jun-juan MA Feng-long QIAO Yan-liang |
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| Abstract: | The synthetic route and improved process for the preparation of cefquinome sulfate were studied. In the presence of trimethyliodosiliane, 7-ACA, which underwent 3-substitution by 5,6,7,8-tetrahydroquinohne and then reacted with AEME, cefquinome sulfate was obtained in 51.9% overall yield. The structure of target substance was determined by elemental analysis, IR and ^1H NMR. This synthetic route is suitable for industrial manufacture. |
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| Keywords: | cefquinome 5,6,7,8-tetrahydroquinolin 7-ACA synthesis |
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