疏血通对原发性肾病综合征血液流变学影响的临床研究

目的观察疏血通注射液对原发性肾病综合征血液流变学的影响及临床疗效。方法原发性肾病综合征患者120例随机分为治疗组60例和对照组60例。治疗组:常规治疗加疏血通注射液静脉点滴。对照组:常规治疗加复方丹参注射液静脉点滴。两组患者分别于治疗前及疗程结束后3天行血液流变学、血常规、尿常规、24小时尿蛋白定量、肝功能、肾功能及血脂等检查。结果两组患者治疗前均存在高粘血症,两组间比较无显著性差异。治疗4周后,治疗组除红细胞压积和红细胞聚集指数外,其余7项指标均显著降低(P<0.01)。对照组除血沉和血沉方程K值外,其余7项指标治疗前后比较无统计学差异(P>0.05)。治疗后治疗组与对照组比较,全血粘度(高、中、低切)、血沉、血沉方程K值、纤维蛋白原有显著差异(P<0.01),血浆粘度差异也有显著性(P<0.05)。总有效率治疗组86.7%,对照组63.3%,治疗组明显高于对照组(X2=4.36,P<0.01)。结论疏血通注射液可明显改善原发性肾病综合征患者的血液高粘及高凝状态,提高原发性肾病综合征的缓解率。

Clinical Study of Shuxuetong Injection on Hemorheology in Primary Nephrotic Syndrome Patients

s Objective:To observe the effect of Shuxuetong injection on hemorheology and therapeutic effect in patients with primary nephrotic syndrome. Methods:120 patients of primary nephrotic syndrome were divided into the treatment group (n=60) and the control group (n=60) randomly. The treatment group were injected shuxuetong injection and conventional therapy while the control group were injected salvia miltiorrhiza compound injection and conventional therapy. Before and after 3 days of treatment course, hemorrheology, blood routine, urine routine, 24 hours urine protein quantity, liver function, renal function and serum lipid were detected in all patients. Results: All patients had hyperviscousemia before treatment. There was no-singificant difference between two groups. After 4 weeks treatment, seven indexes of the treatment groups degraded markedly beside hematocrit and erythrocyte aggregation exponent (P<0.01). Beside the erythrocyte sedimentation rate and the erythrocyte sedimentation rate equation K value, other seven indexes of the control group had no-statistics difference before and after treatment (P>0.05). Compared with the control group after treatment, the whole blood viscosity (high, middle and low cuts), the erythrocyte sedimentation rate, the erythrocyte sedimentation rate equation K value, the fibrin of the treatment group had significant deviation (P<0.01). The plasma viscosity difference was also significant (P<0.05). Total effective rate of the treatment group was 86.7%, and the control group was 63. 3%. The treatment group is higher than the control group obviously (X2 =4.36, P<0.01). Conclusion: The study shows Shuxuetong injection can obviously improve blood hyperviscous and hypercoagulabale state, which can elevate remission rate of the primary nephrotic syndrome patients.