| 新烟碱类杀虫剂的结构与活性及其药效基团 |
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| 引用本文： | 唐振华.新烟碱类杀虫剂的结构与活性及其药效基团[J].现代农药,2002,1(1):1-6. |
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| 作者姓名： | 唐振华 |
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| 作者单位： | 中国科学院上海昆虫研究所,上海,200025 |
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| 摘 要： | nAChRs在昆虫的神经系统的兴奋性神经传导中起着极其重要的作用,并且是杀虫剂的一个重要靶标。本文就以下几方面作了详细的阐述:作用于昆虫nAChRs的各类化学杀虫剂的演绎,nAChRs的结构与活性,烟碱类似物的结构与活性,新烟碱类杀虫剂的结构修饰及其选择性,以及新烟碱类的药效基团。
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| 关 键 词： | 烟碱型乙酰胆碱受体(nAChRs) 新烟碱类杀虫剂 结构与活性 药效基团 |
Structure - Activity and Pharmacophore of Neonicotinoid Insecticides |
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| Tang Zhenhua.Structure - Activity and Pharmacophore of Neonicotinoid Insecticides[J].Modern Agrochemicals,2002,1(1):1-6. |
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| Authors: | Tang Zhenhua |
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| Abstract: | nAChRs play a major role in excitary neurotransmition in insect CNSs and constitute an important target for insecticides. Present paper elucidates the following aspects; evolution of chemical classes of insecticides that act on insect nAChRs, structure and function of nAChRs, structure - activity of nicotine analogs, the structure modified and selectivity of neonicotinoid insecticides, and the pharmacophore of neonicotinoids. |
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| Keywords: | nicotinic acetylcholine receptors (nAChRs) neonicotinoid insecticides structure - activity pharmacophore |
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