Memory-related changes of nitric oxide synthase activity and nitrite level in rat brain |
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Authors: | J Chen S Zhang P Zuo L Tang |
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Affiliation: | Department of Physiology, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. |
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Abstract: | The changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS activity was assayed by conversion of [3H]L-arginine to [3H]L-citrulline, and a sensitive fluorometric assay for quantification of nitrite was used. Compared with sham-trained rats, NOS activity and nitrite level in hippocampus and cortex, and also the nitrite level in cerebellum, was elevated significantly one day after rats had learnt a water-rewarded spatial alteration task. These results suggest a spatial memory-related changes of endogenous NO in rat brain, and support the idea that NO participates in learning and memory processes. |
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