2-氯-6-三氯甲基吡啶的制备研究

采用等质量混合的三乙醇胺与过氧化苯甲酰作为催化剂。在管式反应器中2-甲基吡啶盐酸盐（MPCH）与氯气反应合成了2-氯-6-三氯甲基吡啶（NP），研究了催化剂用量、反应原料、原料配比、加料速率和反应温度对氯化产物中NP含量及制备过程收率的影响。优化反应条件为：采用MPCH作原料，m（催化剂）：m（2-甲基吡啶）=0．01：1，N（C12）：N（MPCH）=6：1，反应温度为180～190℃，MPCH和氯气的较佳进料速率分别为15g／h和49．4g／h，此时氯化产物中NP的含量可达78．5％，制备过程收率达93．4％。氯化反应NP选择性高。工艺简单，易于实现工业化。

A Study on the Preparation of 2-Chloro-6-(trichloromethyl)pyridine

2-Chloro-6-(trichloromethyl)pyridine(NP)was prepared by chlorination of 2-methylpyridine hydrochloride(MPCH)with Cl2 in a gas-liquid countercurrent tubular reactor.A mixture of triethanolamine and benzoylperoxide with identical concentration was used as catalyst.The optimum reaction conditions were as follows:m(Catalyst):m(MP)=0.01:1,n(Cl2):n(MPCH)=6:1,reaction temperature 180～190℃,feed rates of MPCH 15g/h and of Cl2 49.4g/h.Under optimal conditions,the content of NP in chlorination products and the yield of NP reached 78.5% and 93.4%,respectively.