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| 4-甲氧基-3-卤代联苯的合成 | |
| 引用本文： | 陈强,陆荣青,张秀芹,孙小强,崔源.4-甲氧基-3-卤代联苯的合成[J].精细化工,2010,27(4). |
| 作者姓名： | 陈强 陆荣青 张秀芹 孙小强 崔源 |
| 作者单位： | 1. 江苏工业学院化学化工学院,江苏,常州,213164;南京大学常州高新技术研究院,江苏常州213164 2. 南京大学常州高新技术研究院,江苏常州,213164 3. 江苏工业学院化学化工学院,江苏,常州,213164 |
| 摘 要： | 以对甲氧基联苯胺为原料,在-5~0℃下进行重氮化,再与氯化亚铜或溴化亚铜在90℃发生Sandmeyer反应,得到4-甲氧基-3-卤代联苯,考察了原料配比、反应温度和反应时间等对反应的影响,并通过熔点、红外光谱、核磁共振波谱等对其进行了表征。研究结果表明,采用该方法合成的3-氯-4-甲氧基联苯的总收率为63%,3-溴-4-甲氧基联苯的总收率为51%。 |
| 关 键 词： | 4-甲氧基-3-卤代联苯 对-甲氧基联苯胺 重氮化 精细化工中间体 |
Synthesis of 4-Methoxy-3-halogenated Biphenyl |
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| CHEN Qiang,LU Rong-qing,ZHANG Xiu-qin,SUN Xiao-qiang,CUI-Yuan.Synthesis of 4-Methoxy-3-halogenated Biphenyl[J].Fine Chemicals,2010,27(4). | |
| Authors: | CHEN Qiang LU Rong-qing ZHANG Xiu-qin SUN Xiao-qiang CUI-Yuan |
| Affiliation: | 1.School of Chemistry and Chemical Engineering/a>;Jiangsu Polytechnic University/a>;Changzhou 213164/a>;Jiangsu/a>;China/a>;2.High Technology Research Institute of Nanjing University/a>;China |
| Abstract: | 4-Methoxy-3-halogenated biphenyl was synthesized from p-dimethoxybenzidine via diazotization at -5～0℃ and Sandmeyer reaction with cuprous bromide or cuprous chloride at 90℃,some factors affected the reaction, such as the material ratio, the reaction time and temperature were discussed. The structure of the product was confirmed by melting point, IR and ~1HNMR.The resultsshow that the total yield of 3-chloro-4-methoxybiphenyl synthesized by this preparation procedure was 63% and 3-bromo-4-methoxybiphenyl was 51%. |
| Keywords: | 4-methoxy-3-halogenated biphenyl p-dimethoxybenzidine diazotization fine chemical intermediates |
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