Comparative Evaluation of Several Direct Compression Sugars |
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| Authors: | Clive O. Ondari Chester E. Kean C. T. Rhodes |
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| Affiliation: | a Department of Pharmacy, University of Rhode Island, Kingston, RIb California and Hawaiian Sugar Company, Crockett |
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| Abstract: | Three new and two commercially available sugar matrices were comparatively evaluated for several fundamental properties of direct compression powder systems. These properties included: particle size distribution, powder flow (determined by a recording powder flow meter), bulk density and moisture content. The matrices studied were Dipac, Nutab, and California and Hawaiian (C & H) Products A, B, and C. These matrices were formulated in to chewable ascorbic acid, multivitamin, and antacid tablets, and analyzed for: weight uniformity, thickness, diameter, hardness, disintegration, resistance to impact stress, friability, dissolution and effect due to aging.
The data obtained showed that the new products (C & H products) were comparable, and in some cases, even superior to the commercially available ones. |
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