Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer |
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Authors: | J Steinberg R Oyasu S Lang S Sintich A Rademaker C Lee JM Kozlowski JA Sensibar |
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Affiliation: | Departments of Urology, Pathology, and Preventive Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA. |
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Abstract: | Our previous observations in LNCaP cells in vitro demonstrated an association between apoptotic cell death resistance and SGP-2 (Clusterin) overexpression. Accordingly, we hypothesized that high levels of cellular SGP-2 would aid in identifying biologically aggressive prostate cancer cells with unique survival advantages. To test this hypothesis, 40 archival radical prostatectomy and/or biopsy specimens of varying grades of prostate cancer were subjected to immunohistochemical SGP-2 staining. The resulting epithelial stains were quantified subjectively on a scale of 1-3 by four independent observers. Benign prostatic epithelial cells from young donors served as controls and showed a consistently weak staining intensity. In contrast, prostate cancer specimens showed varying degrees of staining intensity that correlated with a Gleason pattern (P = 0.006). This correlation supports the hypothesis that protection from apoptotic death may account, in part, for biologically aggressive tumor behavior. |
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