1,2,3-三氮唑的合成工艺研究 |
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引用本文: | 肖国民,杨为华,宋文哲,谭仁宾. 1,2,3-三氮唑的合成工艺研究[J]. 精细化工中间体, 2002, 32(1): 14-15 |
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作者姓名: | 肖国民 杨为华 宋文哲 谭仁宾 |
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作者单位: | 东南大学化学化工系,江苏,南京,210096 |
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摘 要: | 以对甲苯磺酰肼为原料合成 1,2 ,3 三氮唑。研究了各种工艺条件对收率的影响 ,获得了较佳合成工艺 :用苯作溶剂 ,对甲苯磺酰氯与水合肼配比为 1∶2 (mol) ,在 60~ 70℃下进行缩合反应制得对甲苯磺酰肼 ,收率为 80 6% ;对甲苯磺酰肼与乙二醛以配比 1∶2 7(mol)反应后 ,通入定量的氨气进行环合反应生成 1,2 ,3 三氮唑 ,收率达 66 8%
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关 键 词: | 1,2,3三氮唑 对甲苯磺酰肼 合成 β内酰胺抗生素 |
文章编号: | 1009-9212(2002)01-0014-02 |
修稿时间: | 2001-10-12 |
Study on Synthesis of 1,2,3-Triazole |
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Affiliation: | Department of Chemistry and Chemical Engineering,Southeast University,Nanjing,210096) |
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Abstract: | Some synthetic methods of 1,2,3 triazole were introduced in this article. The process of preparation from p toluene sulfonyl hydrazine was selected for its advantages.Experiments were done to compare the different conditions of reaction, and the optimal condition to synthesis of 1,2,3 triazole was obtained as follows: p toluene sulfonyl hydrazine was prepared by reaction of MeC 6H 4SO 2Cl (a) with H 2NNH 2·H 2O(b) in presence of benzene as solvent and M ratio of a∶b=1∶2 at 60~70℃. Then high purity 1,2,3 triazole was obtained by the reaction of p toluene sulfonyl hydrazide and glyoxal at M ratio 1∶2.7 followed by the treatment of the intermediate with ammonia, the yield over 66.8%. |
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Keywords: | triazole p toluene sulfonyl hydrazine synthesis β lactam antibiotics |
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