Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM |
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| Authors: | T Takeshita T Arita H Asao N Tanaka M Higuchi H Kuroda K Kaneko H Munakata Y Endo T Fujita K Sugamura |
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| Affiliation: | Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan. |
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| Abstract: | We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors. |
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