Measuring the hydrophobicity of lubricated blends of pharmaceutical excipients |
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Authors: | Marcos Llusa Ronald D Snee |
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Affiliation: | a Department of Chemical and Biochemical Engineering, Rutgers University, USA b Metropolitan Computing Corporation, New Jersey, USA c Tunnell Consulting, King of Prussia, PA, USA |
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Abstract: | This paper discusses how the hydrophobicity of lubricated pharmaceutical formulations is affected by process variables such as shear rate and strain. Hydrophobicity is a critical property that affects the dissolution of powder formulations, tablets and capsules as well as the performance of tablet coating and granulation operations. In this paper, hydrophobicity is measured using a modified Washburn method. Results show that, in the absence of lubricant, the hydrophobicity of powders does not change substantially as a function of shear rate or strain. However, when magnesium stearate is present (concentrations studied here range between 0.5% and 2%), hydrophobicity increases as a function of strain, shear rate and lubricant concentration. Observed changes range over several orders of magnitude, readily explaining common “overlubrication” observations of delayed drug dissolution. |
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Keywords: | Wettability Lubrication Dissolution Magnesium stearate |
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