Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion |
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Authors: | Xiaolan Zhang Peter R Chang Junli Li Daxin Wang Jinghua Chen |
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Affiliation: | a College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China b Bioproducts and Bioprocesses National Science Program, Agriculture and Agri-Food Canada, 107 Science Place, Saskatoon, SK S7N 0X2, Canada c Beijing National Laboratory for Molecular Science, Division Polymer Science and Materials, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China d Subei People’s Hospital of Jiangsu Province, Yangzhou University, Yangzhou 225001, China e Interdisciplinary Science and Technology Institute for Advanced Study, East China Normal University, Shanghai 200062, China f State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China g School of Medicine and Pharmaceutics, Jiangnan University, Wuxi 214122, China |
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Abstract: | Polysaccharide nanocrystals, such as the rod-like whiskers of cellulose and chitin, and platelet-like starch nanocrystals, were for the first time incorporated into supramolecular hydrogels based on cyclodextrin/polymer inclusion in order to enhance mechanical strength and regulate drug release behavior. The structures and properties of the resultant nanocomposite hydrogels were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and rheological testing. As expected, the elastic modulus of the nanocomposite hydrogels climbed, owing to the reinforcing function of the polysaccharide nanocrystals. The modulus of the cellulose whisker-doped hydrogel was 50 times higher than that of the native hydrogel. Furthermore, the presence of polysaccharide nanocrystals increased the stability of the hydrogel framework and inhibited the diffusion of bovine serum albumin, which served as a model protein drug in the nanocomposite hydrogels and showed prominent sustained release profiles. Importantly, the incorporation of polysaccharide nanocrystals did not show additional cytotoxicity as comparison with the native hydrogel. In addition, the inherited shear-thinning property of the nanocomposite hydrogels contributed to their potential as injectable biomaterials. |
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Keywords: | Supramolecular hydrogel Cyclodextrin inclusion Polysaccharide nanocrystal |
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