| (2S,4S)-4-羟脯氨酸的合成工艺研究 |
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| 引用本文： | 田苗,柴宗曦. (2S,4S)-4-羟脯氨酸的合成工艺研究[J]. 工业催化, 2015, 23(4): 327-329. DOI: 10.3969/j.issn.1008-1143.2015.04.015 |
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| 作者姓名： | 田苗 柴宗曦 |
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| 作者单位： | 1．兰州石化职业技术学院，甘肃 兰州 730060； 2．兰州交通大学国家大学科技园，甘肃 兰州 73003 |
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| 基金项目： | 科技型中小企业技术创新基金项目 |
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| 摘 要： | 以(2S,4R)-4-羟脯氨酸为基础原料,以水为介质,利用三苯基膦和醇的Mitsunobu合成反应,改变其构型得到(2S,4S)-4-羟脯氨酸。此方法在现有合成路线基础上有所改进,在实验过程中探索反应物配比对各步反应收率的影响,得到实验的最优条件。并对产物进行表征及纯度分析,确定为(2S,4S)-4-羟脯氨酸,纯度为87.2%,收率93.3%。
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| 关 键 词： | 精细化学工程 (2S 4R)-4-羟脯氨酸 (2S 4S)-4-羟脯氨酸 Mitsunobu合成反应 |
Research on the synthesis process of(2S,4S)-4-hydroxyproline |
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| Tian Miao,Chai Zongxi. Research on the synthesis process of(2S,4S)-4-hydroxyproline[J]. Industrial Catalysis, 2015, 23(4): 327-329. DOI: 10.3969/j.issn.1008-1143.2015.04.015 |
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| Authors: | Tian Miao Chai Zongxi |
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| Affiliation: | 1.Lanzhou Petrochemical College of Vocational Technology, Lanzhou 730060, Gansu, China; 2.State University Science Park of Lanzhou Jiaotong University, Lanzhou 730030, Gansu, China |
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| Abstract: | Using (2S,4R)-4-hydroxyproline as the raw material,water as the medium,(2S,4S)-4-hydroxyproline was synthesized through Mitsunobu reaction of triphenylphosphine and alcoheol to change the configuration of (2S,4R)-4-hydroxyproline.This method was improved based on the existing synthetic route.The influence of reactant molar ratios on the yield of each reaction step was investigated.The optimal experimental condition was obtained.The product was characterized by 1HNMR and liquid chromatogram and its purity was analyzed.The product was identified as (2S,4S)-4-hydroxyproline,and its purity and yield were 87.2% and 93.3%,respectively. |
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| Keywords: | fine chemical engineering (2S,4R)-4-hydroxy proline (2S,4S)-4-hydroxy proline Mitsunobu synthetic reaction |
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