白藜芦醇对快速老化鼠学习记忆能力的影响

将4月龄雄性快速老化鼠（SAMP／8）随机分为模型组、白藜芦醇低、中、高剂量组，并以4月龄正常老化鼠（SAMR／1）为对照组．对照组及模型组用生理盐水灌胃，白藜芦醇治疗组给予不同剂量白藜芦醇（25，50，100mg／kg）灌胃．连续治疗8周后，运用Morris水迷宫方法测试各组小鼠的定位航行和空间探索能力．结果发现，SAMP／8鼠的学习记忆能力明显低于同月龄SAMR／1鼠，表现为逃避潜伏期从第2天起显著延长，原平台象限停留时间缩短，游泳速度较慢．给予白藜芦醇8周治疗，SAMP／8鼠逃避潜伏期明显缩短（P〈0．05），原平台象限停留时间显著延长（P〈0．05），游泳速度加快（P〈0．05），且呈现出量效关系．推断白藜芦醇能显著改善SAMP／8鼠方向辨别的学习能力及记忆巩固能力．

Effect of resveratrol on learning and memory ability of senescence accelerated mice

Four-month old SAMP/8 mice were divided into four groups randomly： the model group, low-dose, moderate-dose and high-dose resveratrol groups, and four-month old SAMR/1 mice were in normal control group. The normal control group and model group were given normal saline by gavage, Res-treated mice were administered Res by garage at the daily doses of 25, 50, 100 mg/kg respectively. After medication for 8 weeks, the parameters of place navigation test and spatial probe test in Morris water maze were analyzed. Results showed learning and memory ability in SAMP/8 mice was significantly lower than SAMR/1 mice,manifesting as the prolongation of the escape latency from the second day, the shortening of the time of staying on original platform quadrant, and the slow swimming speed. After treatment Res for 8 weeks, escape latency of SAMP/8 mice was shortened （P〈0.05）, the time of staying on original platform quadrant was prolonged （P〈0.05）, and the swimming speed was quicker, the effect was in dose-dependent. It can be concluded that Res can improve the learning and memory consolidation ability in SAMP/8 mice.