| ~(60)Coγ射线照射对中国仓鼠肺细胞某些生物学指标的影响 |
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| 引用本文： | 汤沛,汪寿芳,张淑贤.~(60)Coγ射线照射对中国仓鼠肺细胞某些生物学指标的影响[J].辐射防护,1988(3). |
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| 作者姓名： | 汤沛 汪寿芳 张淑贤 |
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| 作者单位： | 核工业部辐射防护研究所
(汤沛，汪寿芳)，核工业部辐射防护研究所(张淑贤) |
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| 摘 要： | 本文介绍中国仓鼠肺(CHL)细胞受0.087—10.0Gy 剂量~(60)Coγ射线照射后,细胞群体倍增数、存活率、染色体畸变率和超微结构的变化等观察结果。~(60)Co γ射线诱发的 CHL 细胞染色体畸变中,双着十环的畸变率Y(%)与剂量 D(Gy)的关系可用 y=4.26×10~(-2)D+4.43×10~(-3)D~2表示。CHL 细胞的50%生长抑制剂量为4.0Gy。1.0—10.0Gy 剂量组细胞的超微结构可见线粒体肿胀和空泡化,3.0Gy 组核膜凹陷,5.0Gy 以上剂量组有的细胞核质疏松、核膜多处深陷和核仁消失。扫描电镜观察,1.0和3.0Gy 剂量组细胞表面的皱褶和绒毛减少或消退。
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| 关 键 词： | CHL 细胞 γ射线 存活率 染色体畸变 超微结构 |
EFFECTS OF ~(60)Co GAMMA-RAYS ON SOME BIOLOGICAL CHARACTERISTICS OF CHINESE HAMSTER LUNG CELLS |
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| Tang Pei,Wang Shoufang,Zhang Shuxian.EFFECTS OF ~(60)Co GAMMA-RAYS ON SOME BIOLOGICAL CHARACTERISTICS OF CHINESE HAMSTER LUNG CELLS[J].Radiation Protection,1988(3). |
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| Authors: | Tang Pei Wang Shoufang Zhang Shuxian |
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| Abstract: | The proliferation of cells and the relationship between survivaland dose were investigated in Chinese hamster lung(CHL)cells grown atstationary phase and irradiated with ~(60)Co gamma-rays.The ultrastructuralchanges and chromosome aberration in the cells after irradiation were alsoobserved.The frequency of chromosome aberrations increased linearly withdose and the yields of dicentrics plus rings were best fitted to a linear-quadraticmodel.The 50% growth-inhibited dose wag found to be 4.0Gy.Electronmicroscopy observation revealed swelling and vacuolation of mitochodria andindistinct cristae at lower doses.The alterations in nucleusat higher dosesappeared to be depression of nuclear membrane and disappearance of chromatin. |
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| Keywords: | CHL Cell Gamma-rays Survival Fraction Chromosome Abrretion Ultrastructure |
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