| 13C标记和未标记果糖化赖氨酸"一釜法"合成工艺的研究 |
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| 引用本文： | 刘博,李丹丹,王腾. 13C标记和未标记果糖化赖氨酸"一釜法"合成工艺的研究[J]. 北京石油化工学院学报, 2018, 26(2): 13-17. DOI: 10.12053/j.issn.1008-2565.2018.02.003 |
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| 作者姓名： | 刘博 李丹丹 王腾 |
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| 作者单位： | 中国食品药品检定研究院,北京,100050;北京石油化工学院化学工程学院,北京,102607 |
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| 基金项目： | 北京市教委科研计划一般项目基金资助(KM201610017004) |
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| 摘 要： | 为了能够快速、高效合成果糖化赖氨酸及其~(13)C同位素标记物,分别以~(13)C同位素标记、非标记的葡萄糖和Fmoc保护赖氨酸为原料,通过对阿马德里反应与Fmoc脱除反应的工艺条件进行系统优化,建立了串联"一釜法"合成工艺。该方法大幅提升了果糖化赖氨酸的合成效率,为实现果糖化赖氨酸的工业化生产奠定了基础。
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| 关 键 词： | 果糖化赖氨酸 化学合成 工艺优化 一釜法 |
One-pot Synthetic Process for Fructosyl-Lysine and its 13C Labeled Derivatives |
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| LIU Bo,LI Dandan,WANG Teng. One-pot Synthetic Process for Fructosyl-Lysine and its 13C Labeled Derivatives[J]. Journal of Beijing Institute of Petro-Chemical Technology, 2018, 26(2): 13-17. DOI: 10.12053/j.issn.1008-2565.2018.02.003 |
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| Authors: | LIU Bo LI Dandan WANG Teng |
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| Abstract: | This research reported a tandem one-pot procedure for rapidly and efficiently constructing the fructosyl-lysine and the 13C labeled derivatives by optimizing the synthetic conditions of Amadori reaction and deprotection reaction.This process using non-labeled and 13C labeled glucose and Fmoc-lysine as the starting materials,which could not only improve the synthetic efficiency of fructosyl-lysine and its derivatives,but also could provide the basis for the industrial manufacture. |
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