| 左旋多巴醇在不对称还原中的应用研究 |
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| 引用本文： | 冯瑞.左旋多巴醇在不对称还原中的应用研究[J].化工技术与开发,2011,40(11):5-6,63. |
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| 作者姓名： | 冯瑞 |
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| 作者单位： | 河南南阳医学高等专科学校,河南 南阳,473058 |
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| 基金项目： | 广西科学基金项目资助(桂科基0575055) |
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| 摘 要： | 在NaBH4/Cd2+、NaBH4/Co2+、NaB4/Ce3+、NaBH4/Ni3+还原体系中,采用加入手性源左旋多巴醇和不加入左旋多巴醇两种方法,分别对苯乙酮进行不对称还原,结果表明,加入手性源左旋多巴醇后,反应速度快,产率高.同时在这4种还原体系中NaBH4/Ce3+的催化效果最好.
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| 关 键 词： | 左旋多巴醇 苯乙酮 不对称还原 |
Applied Research on L-dopa Alcohol in Asymmetric Reduction |
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| FENG Rui.Applied Research on L-dopa Alcohol in Asymmetric Reduction[J].Technology & Development of Chemical Industry,2011,40(11):5-6,63. |
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| Authors: | FENG Rui |
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| Affiliation: | FENG Rui(Nanyang Medical College,Nanyang 473058,China) |
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| Abstract: | Asymmetric reduction of acetophentone was prepared by two methods of adding L-dopa Alcohol or no adding L-dopa alcohol with NaBH4/Cd2+ 、NaBH4/Co2+ 、NaBH4/Ce3+ 、NaBH4/Ni3+ as the reducing agent.The optimum conditions were as followed: the method of adding L-dopa alcohol had the advantages of faster reaction speed and higher yield.At the same time,with NaBH4/Ce3+ as the reducing agent was the best of catalytic effect in the four reduction system. |
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| Keywords: | L-dopa alcohol acetophentone asymmetric reduction |
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