| 聚离子复合物胶束的制备及其对辅酶A的控制释放 |
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| 引用本文： | 罗亚莉,姚新建,袁金芳,高青雨.聚离子复合物胶束的制备及其对辅酶A的控制释放[J].功能材料,2009,40(5). |
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| 作者姓名： | 罗亚莉 姚新建 袁金芳 高青雨 |
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| 作者单位： | 河南大学,精细化学与工程研究所,河南,开封,475001 |
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| 基金项目： | 国家自然科学基金资助项目(50273010) |
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| 摘 要： | 用RAFT活性可控聚合法合成了全水亲性嵌段共聚物聚(N-乙烯基吡咯烷酮)-b-聚(2-丙烯酰胺-2-甲基丙磺酸)(PVP-b-PAMPS)和聚(N-乙烯基吡咯烷酮)-b-聚甲基丙烯酸二甲氨基乙酯(PVP-b-PD-MAEMA).二者在水溶液中复合即可形成聚离子复合物(PIC)胶束,并利用动态光散射法(DLS)和透射电镜(TEM)表征了该胶束的粒径、粒径分布以及形貌.研究结果表明,所制备的胶束外形大致呈球状,粒径在155nm左右,且粒径分布较窄.以辅酶A为模型分子,负载在胶束内进行药物控制释放.研究结果表明,辅酶A的释放受溶液pH的影响,该聚离子复合物胶束可以用作药物控释载体.
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| 关 键 词： | 全水亲性嵌段共聚物 聚离子复合物胶束 制备 辅酶A 控制释放 |
Preparation of polyion complex micelles and its controlled release on coenzyme A |
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| LUO Ya-li
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YAO Xin-jian
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YUAN Jin-fang
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GAO Qing-yu.Preparation of polyion complex micelles and its controlled release on coenzyme A[J].Journal of Functional Materials,2009,40(5). |
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| Authors: | LUO Ya-li YAO Xin-jian YUAN Jin-fang GAO Qing-yu |
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| Affiliation: | Institute of Fine Chemical and Engieering;Henan University;Kaifeng 475001;China |
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| Abstract: | Double-hydrophilic block copolymers,poly(N-vinylprrolidone)-block-poly(2-acrylamido-2-methyl-propanesulfonic acid)(PVP-b-PAMPS) and poly(N-vinylprrolidone)-block-poly(N,N-di-methylaminoethyl methacrylate)(PVP-b-PDMAEMA),were synthesized by RAFT-controlled radical polymerization.Polyion complex(PIC) micelles were prepared by mixing PVP-b-PDMAEMA with PVP-b-PAMPS in water.The micellar morphologies and size were studied using transmission electron microscopy(TEM) and dynamic light scattering(DLS).The results s... |
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| Keywords: | double-hydrophilic block copolymers polyion complex micelles preparation coenzyme A controlled release |
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