Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking |
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Authors: | M Hasegawa O Tetsu R Kanno H Inoue H Ishihara M Kamiyasu M Taniguchi M Kanno |
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Affiliation: | Center for BioMedical Science, School of Medicine, Chiba University and CREST of the Japan Science and Technology Corporation. |
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Abstract: | Polycomb group (PcG) genes were initially described in Drosophila melanogaster as regulators of the homeobox gene. Four mammalian homologues, mel-18, bmi-1, M33 and rae-28, are analyzed in this study. They not only regulate mammalian homeotic genes by analogy with their Drosophila counterparts, but also have some influence on the growth and differentiation of B lymphocytes. Here we report that these four mammalian PcG genes are rapidly induced after antigen-receptor cross-linking in B cells. Thus we would like to propose that mammalian PcG genes can be categorized as a new type of immediate early gene. |
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