| 用不对称二羟基化反应合成光学纯( )-(1R,2R)和(-)-(1S,2S)-1,2-二苯基-1,2-乙二胺 |
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| 引用本文： | 张邦乐,张生勇. 用不对称二羟基化反应合成光学纯( )-(1R,2R)和(-)-(1S,2S)-1,2-二苯基-1,2-乙二胺[J]. 化学试剂, 1999, 0(3) |
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| 作者姓名： | 张邦乐 张生勇 |
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| 作者单位： | 第四军医大学化学教研室 |
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| 摘 要： | 以（Ｅ）－１，２－二苯基乙烯为原料，经催化不对称二羟基化反应，生成相应的对映体纯１，２－乙二醇，再分别与甲基磺酰氯和叠氮钠作用，最后催化氢化，生成光学纯１，２－乙二胺，总产率７０％。
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| 关 键 词： | 催化不对称合成，不对称二羟基化，（＋）－（1R.2R）和（－）－（1S.2S）－1.2－二苯基－1.2－乙二胺 |
Synthesis of optically pure( )(1R,2R)and (-)(1S,2S)1,2diphenyl1,2ethylenediamine by asymmetric dihydroxylation |
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| Zhang Bangle,Zhang Shengyong. Synthesis of optically pure( )(1R,2R)and (-)(1S,2S)1,2diphenyl1,2ethylenediamine by asymmetric dihydroxylation[J]. Chemical Reagents, 1999, 0(3) |
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| Authors: | Zhang Bangle Zhang Shengyong |
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| Abstract: | he (E)stilbene 1 is easily converted by the catalytic asymmetric dihydroxylation to corresponding enantiomerically pure diol 2.The transformation of 2 to the mesylate 3 and subsequent nucleophilic substitution with sodium azide affords the diazide 4,which is then reduced by catalytic hydrogenation to the optically pure 1,2diamine 5.The overall yield is 70% |
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| Keywords: | catalytic asymmetric synthesis asymmetric dihydroxylation ( )(1R 2R) or (-)(1S 2S)1 2diphenyl1 2ethylenediamines |
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