脑缺血及再灌注对脑微血管通透性及肺等脏器的影响

在脑缺血及再灌注的动物模型上，利用ＦＬＮａ示踪剂研究软脑膜微血管的通透性，通过测定血液、脑与其它５种脏器的荧光强度及对脑微血管荧光图像初步分析与处理，探讨其内在规律．结果表明，缺血与缺血后再灌注可以引起脑微血管内皮细胞损伤，血液再灌注到一定时间，对损伤有一定的修复；同等条件下，各脏器受损程度不同，其中肝、肾的微血管内皮细胞损伤最重，肺、心次之，脑与脾最轻，即脑、脾微血管抗损能力较强；同时，不同脏器中ＦＬＮａ浓度随时间的衰减规律各不相同，且比较复杂．

The Effects of Post-Ischemic Reperfusion to Cerebral Microvessels and Lung Etc.orgins

The rat model of cerebral ischemia with reperfusion was employed to observe intravital microvessels and to measure the fluorescence intensitics of blood, brain and other five internal organs of the body for studying the permeability of cerebral microvessels with fluorescent tracer FLNa. It was designed to find the effect and inherent law of ischemia with reperfusion to the permeability of cerebral microvessels. Experiment results show that ischemia and ischemia with reperfusion do harm to endothelial cells of the capillary; in this case the permeability was obviously enhanced compared with that in normal condition, and the long duration of reperfusion plays roles in repairing trauma. Under the same conditions, their different fluorescence intensities show that their resistance to ischemia and lacking of oxygen isn' t identical, the degree of harm vanes, considerably in internal organs, where the most serious is the endothelial cells of liver and kidney, the lesser those of brain and spleen. The condition of lung is an exception and the specialty of lung is related to its structure.