| 竹节参总皂苷改善高脂高糖饮食小鼠的神经炎症及可能的机制 |
| |
| 引用本文： | 王东帆,王瑞,袁丁,张长城,刘朝奇,袁成福,周志勇,何毓敏,顿耀艳,王婷.竹节参总皂苷改善高脂高糖饮食小鼠的神经炎症及可能的机制[J].现代食品科技,2018,34(7):8-13. |
| |
| 作者姓名： | 王东帆 王瑞 袁丁 张长城 刘朝奇 袁成福 周志勇 何毓敏 顿耀艳 王婷 |
| |
| 作者单位： | 三峡大学医学院;三峡大学仁和医院;缺血性心脑疾病转化医学宜昌市重点实验室(三峡大学) |
| |
| 基金项目： | 三峡大学学位论文培优基金项目资助；国家自然科学基金资助项目（81374001）；三峡大学重点实验室开放基金（2016KXN05） |
| |
| 摘 要： | 探索了竹节参总皂苷(saponins of Panax Japonicus,SPJ)对高脂高糖饮食诱导小鼠脑组织炎症反应的改善效果。Balb/c小鼠随机分为四组:正常对照组、模型对照组、SPJ低剂量组(16.7 mg/kg),SPJ高剂量组(50 mg/kg),分别给予普通饲料、高脂高糖饲料及添加不同剂量SPJ的高脂高糖饲料,喂养4个月。与正常对照组比较,模型对照组的皮层形态结构异常,细胞凋亡增多,小胶质细胞激活增加,炎症相关因子表达升高。给予竹节参总皂苷干预,可明显改善脑组织形态结构,减少细胞凋亡和小胶质细胞活化,减轻炎症相关因子iNOS、COX-2和IL-1β的蛋白表达,并抑制NLRP3炎症小体包括NLRP3、ASC、Caspase-1的表达。可见,竹节参总皂苷可具有改善高脂高糖饮食小鼠的脑组织炎症反应的效果,其机制可能与抑制NLRP3炎症小体的激活从而减少炎症因子表达有关。
|
| 关 键 词： | 竹节参总皂苷 高脂高糖饮食 炎症反应 NLRP3炎症小体 |
| 收稿时间： | 2018/3/7 0:00:00 |
Improvement of Neuroinflammation in Mice Induced By High-Fat-High-Fructose Diet by Saponins of Panax Japonicus and the Possible Underlying Mechanism |
| |
| WANG Dong-fan,WANG Rui,YUAN Ding,ZHANG Chang-cheng,LIU Zhao-qi,YUAN Cheng-fu,ZHOU Zhi-yong,HE Yu-min,DUN Yao-yan and WANG Ting.Improvement of Neuroinflammation in Mice Induced By High-Fat-High-Fructose Diet by Saponins of Panax Japonicus and the Possible Underlying Mechanism[J].Modern Food Science & Technology,2018,34(7):8-13. |
| |
| Authors: | WANG Dong-fan WANG Rui YUAN Ding ZHANG Chang-cheng LIU Zhao-qi YUAN Cheng-fu ZHOU Zhi-yong HE Yu-min DUN Yao-yan and WANG Ting |
| |
| Affiliation: | (1.College of Medical Science, China Three Gorges University, Yichang 443002, China),(1.College of Medical Science, China Three Gorges University, Yichang 443002, China),(2.Ren-He Hospital of China Three Gorges University, Yichang 443001, China),(1.College of Medical Science, China Three Gorges University, Yichang 443002, China),(1.College of Medical Science, China Three Gorges University, Yichang 443002, China),(1.College of Medical Science, China Three Gorges University, Yichang 443002, China),(1.College of Medical Science, China Three Gorges University, Yichang 443002, China),(1.College of Medical Science, China Three Gorges University, Yichang 443002, China),(1.College of Medical Science, China Three Gorges University, Yichang 443002, China) and (3.Yichang Key Laboratory of Ischemic Cardiovascular and Cerebrovascular Disease Translational Medicine (Three Gorges University), Yichang 443002, China) |
| |
| Abstract: | |
| |
| Keywords: | total saponis of Panax japonicus C A Mey high-fat-high-fructose diet inflammation NLRP3 inflammasome |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《现代食品科技》浏览原始摘要信息 |
|
点击此处可从《现代食品科技》下载全文 |
|
