| 2-甲基-5-乙烯基吡啶的合成研究 |
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| 引用本文： | 蒋成君,程桂林. 2-甲基-5-乙烯基吡啶的合成研究[J]. 化学试剂, 2012, 34(9): 845-846,848 |
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| 作者姓名： | 蒋成君 程桂林 |
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| 作者单位： | 1. 浙江科技学院生物与化学工程学院,浙江杭州,310023
2. 杭州宝凯生物化学品有限公司,浙江杭州,310013 |
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| 基金项目： | 浙江省重点创新团队项目 |
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| 摘 要： | 以6-甲基烟酸甲酯为起始原料,经过还原、氧化、Wittig反应合成了标题化合物,3步总收率66.7%,产品经1HNMR和元素分析表征。该方法具有操作简单、成本低等优点,适合工业化生产。
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| 关 键 词： | 2-甲基-5-乙烯基吡啶 6-甲基烟酸甲酯 还原 氧化 Wittig反应 |
Synthesis of 2-methyl-5-vinylpyridine |
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| JIANG Cheng-jun , CHENG Gui-lin. Synthesis of 2-methyl-5-vinylpyridine[J]. Chemical Reagents, 2012, 34(9): 845-846,848 |
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| Authors: | JIANG Cheng-jun CHENG Gui-lin |
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| Affiliation: | 1.School of Biological and Chemical Engineering,Zhejiang University of Science and Technology,Hangzhou 310023,China;2.Hangzhou Baokai Chemcial Co.,Ltd.,Hangzhou 310013,China) |
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| Abstract: | 2-Methyl-5-vinylpyridine was synthesized via reduction,oxidation and Wittig reaction by using methyl 6-methylnicotinate as the starting material.The total yield over three steps was 66.7%.The structure of the product was confirmed by 1HNMR and elementary analysis.This method shows many advantages,such as easy operation and low cost,which can be feasible to large scale preparation. |
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| Keywords: | 2-methyl-5-vinylpyridine methyl 6-methylnicotinate reduction oxidation Wittig reaction |
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