Separation and identification of a novel tadalafil analogue adulterant in a dietary supplement |
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| Authors: | Yen-Chun Huang Yun-Lian Lin Chia-Ying Li Chia-Fen Tsai Hwei-Fang Cheng |
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| Affiliation: | 1. Division of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC);2. Division of Chinese Medicinal Chemistry, National Research Institute of Chinese Medicine, Taipei, Taiwan (ROC);3. Department of Applied Chemistry, National Pingtung University, Pingtung City, Taiwan (ROC) |
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| Abstract: | A novel tadalafil analogue found in a dietary supplement by routine drug-adulteration screening was isolated by column chromatography and HPLC. On the basis of extensive 1D- and 2D-nuclear magnetic resonance (NMR), infrared (IR) and mass spectral analyses, the structure of the new compound YJ-02 was established as 6‐(benzod]1,3]dioxol‐5‐yl)‐2,3,6,7,12,12a‐hexahydro‐2‐(1E,2E)‐3‐phenylallylidene)amino)pyrazino1?,2?:1,6]pyrido3,4‐b]indole‐1,4‐dione. Its common name is N-phenylpropenyltadalafil. |
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| Keywords: | Tadalafil analogue N-phenylpropenyltadalafil adulterated food supplements |
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