基于增量制造的再生骨支架制备路径规划方法

基于增量制造的再生骨支架制备方法在生物制造领域表现出巨大应用潜力，也越来越受到重视，其中制造路径规划方法直接影响到制备的支架的结构特点，在很大程度上决定了后期支架的细胞培养以及组织修复效果。目前典型的面向工业以及民用领域的增量制造工艺的路径规划方法不能完全适用于骨支架的制备，无法获得能够有效模拟细胞外基质结构特征的三维贯通结构。针对这一问题，提出一种面向生物增量挤出成形技术的再生骨支架制备路径规划方法，将材料成形过程中出现的尺寸变形的补偿融入到路径规划方法的设计中，能有效满足骨支架制备时对复杂外轮廓和梯度孔隙结构的需求。在此基础上，给出再生骨支架增量挤出成形系统的软件系统架构，实现方法及结果，并通过支架成形试验验证支架的性能，研究成果对自主开发生物增量制造装备具有重要价值和意义。

The Method of Path Planning for the Regenerated Bone-scaffold Preparation Based on Additive Manufacturing

The regenerated bone-scaffold preparation method based on additive manufacturing shows great potential for application in the field of biological manufacturing and has been paid more and more attention to. The path planning methods directly affects the structure characteristics of the prepared scaffold, which largely determines the final cell culture and tissue repair effects. Currently the path planning methods in typical additive manufacturing for industrial and civil fields cannot be fully applied to the preparation of bone scaffolds, and the three-dimensional structure which effectively simulates extracellular matrix structure characteristics cannot be obtained. To solve this problem, the method of path planning is proposed for biological regenerated bone scaffold preparation based on additive extrusion manufacturing. The compensation of the material size deformation in the forming process is considered in this method, which effectively meets the demand for complex contour and gradient pore structure. On this basis, the software system architecture of the additive extrusion forming system for regenerated bone scaffold, as well as the implementation methods and results is given. Finally, the performance of the scaffold is verified through the forming experiment. The research results provide important value and significance on the development of biological additive manufacturing equipment.